Mitigating Risk Roche’s Approach to PAT Implementation in a Sodium Borohydride Product

Jul 27, 2017

Many compounds are synthesised from raw materials in multi-batch and multi-ton quantities over extended time periods. The repetitious nature of the multi-batch business has proven a rich source of opportunity for process analytical technologies (PAT) applications at Roche, for over 15 years in some cases. The key focus has been the integration of the PAT applications into the existing manufacturing systems such as automation, IT, QC, QA, maintenance, and R&D, to mitigate risk and improve process efficiently. This case study, written by Dr John O’Reilly, PAT Technology at Roche, specifically looks at the approach to PAT implementation on one such process ...

Read More

Innovations for Prefillable Syringes

Jul 27, 2017

The field of prefillable syringes is constantly turning up new trends and developments, driven by new active ingredients and a desire for patient safety at affordable costs. As a manufacturer of prefillable syringe systems, we respond to these trends with a series of new developments and improvements in accordance with the demands of the pharmaceutical industry, doctors and nursing staff, and the patients themselves. Bernd Zeiss, Manager, Technical Support Medical Systems Business Development at Gerresheimer Bünde GmbH, reviews the innovations of prefillable syringes. ...

Read More

Simplified Bioprocess Setup through Automated Process Control

Apr 11, 2017

Learning to use a bioprocess controller is a complex and often intimidating endeavor for the beginner. Indeed, even with previous bioprocess experience, moving to a new software platform can entail much learning and reduce efficiency. Although many textbooks and manuals exist on the subject, they are no substitute for hands-on experience. Ulrike Becken and her team at Eppendorf AG Bioprocess Center explain how automated process control can help users who are less familiar with bioreactors and fermenters. ...

Read More

Antimicrobial Copper vs Antimicrobial Resistance

Apr 11, 2017

The antimicrobial properties of copper have become widely known, harnessed by hospitals around the world in the form of touch surfaces that continuously reduce bioburden. Now, a potential role in combatting antimicrobial resistance is being proposed by researchers. In his article, Bryony Samuel at Copper Development Association describes some of the latest developments in antimicrobial copper, looking at new science, its growing inclusion in guidelines and ratings systems, and a high-profile installation at a leading London research facility. ...

Read More

Reducing Particulate from Metal Products in Medical Devices

Jan 8, 2016

As the medical device market evolves to become highly sophisticated and advanced, metal part manufacturers face constant pressures in being able to reduce particulate in the production and assembly of components. For medical device component manufacturers, developing new methods to reduce particulate is becoming increasingly important. Graham Perkins, Medical Sales Manager at Advanex, discusses the reduction of particulate from metal products in medical devices. ...

Read More