Optimised Commissioning of Control systems Pre-Parameterisation of Control Systems Facilitates their Planning and Commissioning

Apr 28, 2012

In the commissioning of control systems, coordination problems between the selected individual components occur quite frequently. Dr Egon Huefner, of Bürkert Fluid Control Systems, discusses a new, integrated controller concept with pre-parameterised control systems and defined components that prevents these problems and ensures fast, trouble-free commissioning. ...

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Next-Generation Instrument Discovers Low Affinity Inhibitors of the Inositol Phosphate Pathway

Apr 28, 2012

Traditional high-throughput screening (HTS) strategies searching for single targets have not led to a high number of promising leads for new drugs. Hence pharmaceutical companies are now increasingly looking for multi-target drugs to investigate. Dr E J Dell of BMG LABTECH explains how a next-generation photomultiplier- (PMT-) based instrument was compared to a high-performance charged coupled device (CCD), and how a next-generation HTS microplate reader provides a new more economical tool for finding lower affinity drug discovery compounds via traditional HTS bioassays. ...

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Unfolding the Science of Senescence

Apr 28, 2012

The ever ageing global population has led to an increasing prevalence of protein misfolding diseases, which underlie a number of serious and chronic degenerative conditions. The misshapen structures of these abnormal proteins make them aggregation-prone, leading to the formation of toxic aggregates that underlie various disease pathologies. As the details of the science of this process continue to unfold, new therapeutic approaches to combat this fundamental mechanism of senescence are now emerging. Dr Mark Treherne, Chief Executive at Senexis, explains that as our understanding of the science underlying this fundamental pathological process continues to evolve, we will come ever closer ...

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Drug Discovery: Reversed-Phase High Pressure Liquid Chromatography for Protein/Peptide Identification

Apr 28, 2012

Scientists typically perform unbiased protein identification by directly coupling reversed-phase high pressure liquid chromatography (HPLC) via electrospray ionisation to a mass spectrometer. Unlike innovations in mass spectrometric instrumentation, cutting-edge technology in reserved-phase HPLC has generally not been well adopted in drug discovery. Remco Swart at Thermo Fisher Scientific describes the effects of increased peak capacities on the number of identified proteins and peptides in complex mixtures utilising an RSLCnano LC system, providing a rationale for using advanced reversed-phase HPLC technology coupled with tandem mass spectrometry (HPLC-MS/MS). ...

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Molecular Imaging in Preclinical Research and Drug Development

Apr 28, 2012

Drug development is a lengthy process; development durations of 10–15 years are commonplace when following the established paradigms. Zheng Jim Wang and Mark R. Lane of MPI Research explain that a recent shift in drug discovery efforts, utilising novel biomarkers against specific molecular targets highlights, has seen the need for robust molecular imaging platforms to provide specific endpoints. ...

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