A Winner Emerges in the War Against Microbes

Dec 11, 2012

Man has benefited from copper’s inherent antimicrobial properties since the dawn of civilisation, yet it is only in the last 10-20 years that scientific studies have been conducted to properly evaluate the metal’s potential in reducing contamination in critical environments such as hospitals and food processing facilities.  Angela Vessey at Copper Development Association looks into why in the healthcare sector, the level of laboratory and clinical evidence has stimulated demand for incorporating copper into touch surface hot-spots in the fight against healthcare-associated infections (HCAIs).     [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2012/12/1-A-Winner-Emerges-in-the-War-Against-Microbes.pdf” type=”pdf”]A Winner Emerges in the War Against Microbes[/prettyfilelink] ...

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Cytomics: Managing Biocomplexity in Drug Development, Clinical Diagnostics, and Clinical Medicine

Dec 10, 2012

Cytomics, the science of analysis at the cellular level, objectively accounts for functional phenotypes in the context of the entire organism. Furthermore, the cytomics top-down approach of data analysis does not depend on prior knowledge of disease mechanisms, thus significantly simplifying the exploration of organismal biocomplexity and shortening the path for applications in drug development, clinical diagnostics, and clinical medicine.  Dr Yvon at BioSciences Expansion and Dr Turner at Quintiles provide an introduction to cytomics and its applications through a review of the literature, focusing on genetics, genomics, and other ‘omics’. [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2012/12/3-Cytomics-Managing-Biocomplexity-in-Drug-Development-Clinical-Diagnostics-and-Clinical-Medicine.pdf” type=”pdf”]Cytomics- Managing Biocomplexity in Drug Development, Clinical Diagnostics, and Clinical Medicine[/prettyfilelink] ...

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Conducting Non-clinical Studies with Protein Biologics: Considerations in Test Article Characterisation and Method Development for Dose Formulation Analysis

Dec 10, 2012

With the increase in the number of protein biologics in development, including monoclonal antibodies, the proportion of GLP studies conducted for protein test articles has correspondingly increased.  Therefore, current GLP practices may need to be adjusted to accommodate the physiochemical characteristics of protein test articles. In terms of method development for non-clinical dose formulation analysis, analytical techniques specific to protein biologics will need to be used. Karina Kwok at MPI Research describes the current best practices applied in her organisation for test article characterisation and analytical method development of protein biologics for non-clinical dose formulations. [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2012/12/2-Conducting-Non-clinical-Studies-witn-Protein-Biologics-Considerations-in-Test-Article-Characterisation-and-Method-Development-for-DoseFormulation-Analysis.pdf” type=”pdf”]Conducting Non-clinical Studies witn Protein Biologics- Considerations ...

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Stem Cells and Drug Discovery

Dec 10, 2012

Stem cells are extraordinary cells, having many features and advantages that could revolutionise drug development and healthcare applications. Lilian Hook at Plasticell Limited discusses how they are capable of both self-renewal and differentiation to mature somatic cells in vivo and in vitro, and as such offer a limitless, consistent supply of physiologically relevant cells for applications such as cell replacement therapies, drug development and disease modelling.   [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2012/12/2-Stem-Cells-and-Drug-Discovery.pdf” type=”pdf”]Stem Cells and Drug Discovery[/prettyfilelink] ...

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Homocysteine and Cognitive Impairment

Dec 10, 2012

One consequence of vitamin B12 deficiency is a raised blood level of homocysteine. This non-essential amino acid is derived from dietary protein. Its conversion to useful metabolites requires methyl-folate and vitamins B12 and B6 as cofactors. Blood levels of homocysteine therefore rise with deficiency of these important vitamins. Andrew McCaddon, Honorary Senior Research Fellow in the School of Medicine at Cardiff University, provides a case study of his finding of low B12 levels in families with early onset dementia and his search for evidence of deficiency in patients with late onset dementia.   [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2012/12/1-Homocysteine-and-Cognitive-Impairment.pdf” type=”pdf”]Homocysteine and Cognitive Impairment[/prettyfilelink] ...

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