The Benefits of Bacillus-derived Hyaluronic Acid

Jun 27, 2013

In Adding New and Improved Attributes to Existing Drug Formulations, and Offering Opportunities for New Delivery System Development Jaypreet Dhillon, Editorial Manager at IPI, interviews Hans Ole Klingenberg at Novozymes Biopharma on the benefits and advances of the Bacillus-derived hyaluronic acid, and how this is adding new and improved attributes to the life-science industry, with progress in drug formulations and opportunities in new delivery system development. The interview highlights the potential of hyaluronic acid for drug delivery, and looks at concerns from the FDA, EMA and other regulatory bodies on its commercial availability; its advantages/ disadvantages; and how this technology ...

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Preactivated Thiomers: A New Generation of Mucoadhesive Polymers

Jun 27, 2013

Since the concept of mucoadhesion was pioneered in the early 1980s, various attempts have been made to improve the adhesive properties of polymers. These attempts include approaches such as mucoadhesion by a sustained hydration process, and the development of polymer-lectin conjugates and of polymer-bacterial adhesion conjugates. Andreas Bernkop-Schnürch at ThioMatrix GmbH looks into mucoadhesive polymers, and how they have in many cases not proven to be effective as ‘pharmaceutical glue’ in order to keep drug delivery systems for a prolonged time period on the target mucosal membranes. [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2013/06/3-Preactivated-Thiomers.pdf” type=”pdf”]Preactivated Thiomers[/prettyfilelink] ...

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Optimising Short-Lived Isotopes for Quantitative Whole-Body Autoradiography in Drug Development

Jun 27, 2013

Quantitative whole-body autoradiography (QWBA), which has brought many improvements to the realm of tissue distribution, has itself been improved recently by the expanded use of short-lived isotopes. Andrea Knapp and Brian Knapp at MPI Research explain how this expansion increases options for better imaging and more specific data regarding tissue distribution due to increased resolution of QWBA images, as compared to PET or SPECT images. [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2013/06/2-Optimising-Short-Lived-Isotopes-for-Quantitative-Whole-body-Autoradiography-in-Drug-Development.pdf” type=”pdf”]Optimising Short Lived Isotopes for Quantitative Whole body Autoradiography in Drug Development[/prettyfilelink] ...

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Virtual Drug Development: Vision, Oversight and Risk Management

Jun 27, 2013

The previous article examined how drug development has changed over the last century, whilst highlighting the theme of the increased complexity of drug development. In this follow-up article, Keith J. Williams and Bryan Hurst at Boyd Consultants looks at how many new drugs are being discovered within universities and start-up biotechnology companies. The general problems of sourcing and managing development resources, dealt with in this paper, apply to both of these types of organisations, though the actual development issues will differ. [prettyfilelink src=”http://ipimediaworld.com/wp-content/uploads/2013/06/1-Virtual-Drug-Development.pdf” type=”pdf”]Virtual Drug Development[/prettyfilelink] ...

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