Small Changes to Tablet Shape Bring Big Results

Oct 1, 2014

Tablet shape is generally given the most consideration as new products are branded by marketing departments, whereas whole campaigns have been built around a tablet’s colour or shape. Dale Natoli of Natoli discusses the importance of considering the potential of small adjustments to tablet shape to influence everything from production efficiency to consumer acceptance. An improper tablet design can cost millions in lost production and possibly lead to a disastrous product launch. ...

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When Two is Better than One: The Benefits of Two-Floor Production Facilities for Future-Proof Manufacturing Capability

Oct 1, 2014

The impact of batch transfer methods on the ‘Lean success’ of a plant is starting to be recognised earlier in the plant design process. Before deciding on building and process room heights, proper attention must be given to materials handling processes. A single-floor facility design is simply not flexible enough, and a multiple-floor plant could well be too expensive. A two-floor facility is a good compromise as it provides good agility for future demands with a modest investment requirement. Wim Spook of Matcon looks into the pros and cons of these different facility designs, exploring the benefits to the future ...

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Tailor-made Product Attributes

Oct 1, 2014

Mark Riemer of SternMaid GmbH & Co.KG explores fluid-bed technology, a formative drying process enabling a specific influence on the physical properties of solid and liquid products and their possible applications. Fluid-bed technology opens up an enormous range of possibilities for optimising products – from better solubility, dust reduction, easier tabletting and fortification with vitamins to microencapsulation of active ingredients. Very gentle handling of the products and the diversity of the possible applications have made fluid-bed processing one of the most important formulation methods in the food and pharmaceutical industries. ...

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Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-Formulating Complex Reference Products

Oct 1, 2014

In its report “Critical Path Opportunities for Generic Drugs”, the FDA emphasises the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Gurfateh Singh and Paul Kippax of Malvern Instruments highlight techniques that are especially helpful in the de-formulation of complex reference products, focusing on triple detection Size Exclusion Chromatography (SEC) and Morphologically-Directed Raman Spectroscopy (MDRS). ...

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