Revisited Cell Cultures and Valuable Methods for Pre-clinical Studies

Dec 17, 2014

During the last ten years, the development of transgenic techniques has rendered possible the creation of mutant strains of rodents mimicking human diseases and the assessment of the role of biochemical lesions in their development. However, maintaining and expanding colonies of transgenic rodents is time-consuming, expensive and above all, the characterisation (phenotyping) of these new animals needs highly experienced people. Pr. Philippe Poindron of Neuro-Sys looks into the development of alternative methods for studying efficiency and mode of action of new compounds in preliminary preclinical studies. ...

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Special Report – How to Ensure the Proper Behaviour of Excipients and their Best Possible Use

Dec 17, 2014

As in recent years excipients have proved to be anything but “inert”, ensuring the proper behaviour of excipients in the various phases of the industrial production process has become one of the missions of the pharmaceutical Application Development Centres in France, the USA and China. Cecilia Stroe, Editor of IPI, takes you to Lestrem, France, to the high-technology pharmaceutical Application Development Centre recently inaugurated by Roquette Group, a key supplier of excipients and active ingredients globally. ...

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The Expanding Role of MRI in the Pharmaceutical Industry

Dec 17, 2014

With ever-increasing pressure on drug development pipelines and a growing need to demonstrate convincing mechanisms of action as a part of the registration process for new drugs, innovative methods are being sought that can streamline the traditional drug development process. Matt Wall of Imanova proves that imaging methods have a substantial potential to impact the development and clinical trials process at several stages, and have begun to be used as a method of bolstering the uptake and marketing of already-marketed compounds. ...

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Developing Healthcare Facilities

Dec 17, 2014

If you are the operator of a nursing or care home, and you are considering commissioning the building of a new care or nursing home, or extending or refurbishing an existing building, you should consider taking advice on the terms of appointment of architects and other design consultants, as well as on the appropriate form of building contract. Andrew James of Harrison Clark Rickerbys provides information on a specialist construction unit whose members are very experienced in the procurement of healthcare facilities and resolving any issues which can arise out of them. ...

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ISO IDMP – Four Challenges in Preparing Organisations for the July 1, 2016 EMA Deadline

Dec 17, 2014

Most pharmaceutical companies face challenges in becoming compliant with the ISO IDMP standards. In this article, Rune Bergendorff, responsible for NNIT’s ISO IDMP services shares experience from NNIT’s IDMP work for a handful of pharmaceutical companies over the past two years, letting you in on the conclusions from the IDMP Experience Exchange Group where another handful of pharmaceutical companies shared their insights. ...

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