Temperature-controlled Packaging: More Than Just an Insulated Box

Jul 19, 2016

The demand to frequently transport temperature-sensitive products with greater compliance and often in more difficult conditions is increasing. This places temperature-controlled packaging manufacturers under immense pressure to achieve temperature stability in more efficient and robust ways. This has resulted in a marked shift in the temperature-controlled packaging sector, as manufacturers are having to provide increasingly sophisticated packaging solutions, to ensure that the high-value payloads reach their destination on time and intact. Neil Sherman, Technical Services Manager at Intelsius, explains why temperature-controlled packaging is more than just an insulated box. ...

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Genomics and Precision Medicine: Marketing Challenges and Opportunities

Jul 19, 2016

In an age of big data, companies now have more power to respond to their customers as individuals. Ever since the first internet shops discovered that tracking users’ buying habits could help them to predict what other products users might be interested in, a personalised and tailored service is something companies strive to deliver and consumers increasingly expect. Within this editorial, Jan Van den Burg at Veeva Systems shares his thoughts on genomics and precision medicine, reflecting on marketing challenges and opportunities. ...

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Systemic Epigenetic Biomarkers for ALS Improve Early Diagnosis, Treatment, and Trials

Jul 19, 2016

Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is a devastating, rapidly progressive and invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles and for which there is no diagnostic or prognostic test. The disease belongs to a group of disorders known as motor neuron diseases (MNDs), characterised by the gradual degeneration and death of motor neurons. ALS is one of the most common neuromuscular diseases worldwide, affecting around 2 in 100,000 people each year. Magdalena Jeznach, BSc MSc, ALS Project Manager at Oxford Biodynamics Ltd, focuses on systemic epigenetic biomarkers for ALS. ...

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Engineering of Enzymes for Industrial Biocatalysis

Jul 19, 2016

Enzymes are important biocatalysts with many applications in medicine, food technology and the chemical industry. To further expand their reaction scope and to meet the demands of industrial processes, the enzymes’ properties are routinely optimised by protein engineering. Due to a rapidly increasing number of protein sequences and structures and powerful computational tools, rational approaches are nowadays complementing random approaches. However, in most cases combined approaches prove to be most successful. Dr Kerstin Steiner, Project Manager and Senior Researcher at the Austrian Center of Industrial Biotechnolgy (ACIB) submits a white paper on enzyme engineering for industrial biocatalysis. ...

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Where are the Gaps in your Data?

Jul 19, 2016

In drug discovery, data is king. Gathering the right information makes it easier to design better compounds, faster. How can you be sure that you are getting the most out of your SAR data? And how easy is it to see where the gaps are in your data? A typical lead optimisation phase of a drug discovery project will gather many thousands of data points. Hundreds, or even thousands, of compounds will be synthesised over the course of the project, and each of these compounds has an associated wealth of potency, selectivity and ADMET information. Katriona Scoffin and Giovanna Tedesco ...

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